Bigthink: Microdosing psilocybin for anxiety and depression? A placebo may be just as good

But does microdosing really work? That was the main question behind a recent placebo-controlled study that explored whether microdosing psilocybin — the main hallucinogenic chemical in “magic” mushrooms — improves anxiety, depression, and the overall awareness of what’s happening inside your body. Published in the Journal of Psychopharmacology, the study found no evidence supporting the claim that microdosing psilocybin yields therapeutic benefits.